human APO-1/Fas FlowCytomix Simplex

• 产品编号：BMS80245FF      品牌：eBioscience       原厂货号：BMS80245FF
• 产品分类：ELISA及其它免疫分析 > 其它免疫检测 > CBA基于微球的免疫分析-流式细胞术
• 应用分类：

描述：

Description: This FlowCytomix Simplex Kit is designed for the measurement of Human sAPO-1/Fas in an immunoassay analyzed on a flow cytometer. Together with the FlowCytomix Human Basic Kit (cat. BMS8420FF), this kit can be used to detect sAPO-1/Fas alone or can be multiplexed with other Simplex Kits to measure a variety of analytes.

This kit contains bead population A3.

Programmed cell death or Apoptosis is the most common form of eukaryotic cell death and is found during tumor regression and embryonic development. In the process of selection and eliminiation of autoreactive B and T cells Apoptosis is an important process and therefore a prerequisite for the homeostasis of the immune system. Apoptosis is characterized by changes in cellular morphology (e.g. nuclear condensation, membrane bleeding) and biochemically by rapid induction on DNA fragmentation.
APO-1/Fas (CD95), a member of the TNF/NGF receptor superfamily, is a glycosylated 48 kDa surface protein containing a single transmembrane region. APO-1/Fas is expressed on a variety of human B and T cell lines, on many different tumor cells and on various normal human tissues. Triggering of APO-1/Fas by its ligand or by certain anti-APO-1/Fas monoclonal antibodies results in rapid induction of programmed cell death (Apoptosis) in susceptible cells. The tissue distribution of APO-1/Fas and of the APO-1/Fas ligand suggests that the APO-1/Fas receptor/ligand system plays an important role in various aspects of mammalian development and especially in the homeostasis of the immune system.
Expression of the APO-1/Fas cell surface protein is enhanced by IFN-gamma and TNF and by activation in lymphocytes. APO-1/Fas also occurs in a soluble form (sAPO-1/Fas) devoid of a transmembrane region.
Elevated sAPO-1/Fas levels have been reported in sera from patients with high-and low-grade malignant B- and T-cell leukemias and systemic lupus erythematosus (Knipping et al., submitted). sAPO-1/Fas may prevent cells from undergoing APO-1/Fas ligand induced Apoptosis. Hence, secretion of sAPO-1/Fas may provide a mechanism for tumor cells to excape immunosurveillance and may be involved in leukemogenesis.

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