Description: The monkey IL-12 p70 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of monkey IL-12 p70. The monkey IL-12 p70 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
IL-12 exerts a variety of biological effects on T and natural killer cells. Apart from promotion of Th1 development and its ability to promote cytolytic activity it mediates some of its physiological activities by acting as a potent inducer of IFN-gamma production and the stimulation of other cytokines from peripheral blood T and NK cells. IFN-gamma then enhances the ability of the phagocytic cells to produce IL-12 and other proinflammatory cytokines. Thus, IL-12 induced IFN- gamma acts in a positive feedback loop that represents an important amplifying mechanism in the inflammatory response to infections.
Its role in directing development of a Th1 type immune response from naive T cells demonstrates its critical role in regulation of the immune response and strongly suggests its potential usefulness in cancer therapy.
Components
Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to monkey IL-12 p70
Biotin-Conjugate anti-monkey IL-12 p70 monoclonal antibody
Streptavidin-HRP
Monkey IL-12 p70 Standard lyophilized, 500 U/ml upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films
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