Description: The rat MCP-1 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of rat MCP-1. The rat MCP-1 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.
MCP-1was characterized as a monocyte-specific chemoattractant that was later shown to attract also T lymphocytes and NK cells.
MCP-1 is mainly expressed by macrophages in response to a wide range of cytokines such as IL-6, TNF-alpha and IL-1beta, but can, upon stimulation, also be produced by a variety of cells and tissues, such as fibroblasts, endothelial cells or certain tumor cells.
Because of its target cell specificity, MCP-1 was postulated to play a pathogenic role in a variety of diseases characterized by mononuclear cell infiltration, including atherosclerosis, rheumatoid arthritis and allergic responses. In basophils, MCP-1 is highly effective as a stimulus of histamine release but has only weak chemotactic activity. Additionally it has been shown to chemoattract CD4+ and CD8+ T lymphocytes.
Components
Aluminium pouch(es) with a Microwell Plate coated with Monoclonal Antibody to rat MCP-1, Biotin-Conjugate (anti-rat MCP-1 antibody), Streptavidin-HRP and Sample Diluent, lyophilized
Aluminium pouch(es) with a rat MCP-1 Standard curve (coloured)
Wash Buffer Concentrate 20x (phosphate-buffered saline with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Sample Diluent
Stop Solution (1M Phosphoric acid)
Adhesive Plate Covers
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