MO IL-23 COATED ELISA

• 产品编号：BMS6017      品牌：invitrogen       原厂货号：BMS6017
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: The mouse IL-23 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of mouse IL-23. The mouse IL-23 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

>Interleukin-23 was found during a genome scan for the IL-6/IL-12 cytokine family. IL-23 protein is a heterodimer, sharing a p40 subunit with IL-12, but having a distinct p19 subunit, which is IL-23 specific. IL-23 uses many of the same signal-transduction components as IL-12, so it binds to IL-12Rbeta1 receptor, but not IL-12Rbeta2.
IL-23 plays a role in type 1-polarized T-cell immune responses. Although IL-12 strongly activates naive T-cells, the initial description of IL-23 reported preferential actions on memory T-cells to increase IFN-gamma production and proliferation suggesting an important role for IL-23 in controlling bacterial infections. IL-23 has further been described as a key cytokine controlling inflammation in peripheral tissues. Overexpression of p19 correlates with inflammation in multiple organs and epithelial tissues including skin. IL-23 was shown to be involved in inflammation of the nervous system and autoimmune diseases.

原厂资料：