MO RANTES INSTANT ELISA

• 产品编号：BMS6009INST      品牌：invitrogen       原厂货号：BMS6009INST
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: The mouse RANTES Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of murine RANTES. The mouse RANTES Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.

RANTES (Regulated upon Activation, Normal T cell Expressed and presumably Secreted), also known as CCL5, is a member of the CC chemokine familiy of inflammatory and immunoregulatory cytokines.

Similar to other CC chemokines RANTES is a potent chemoattractant for a number of different cell types including monocytes, unstimulated CD4+/CD45RO+ memory T-cells, stimulated CD4+ and CD8+ Tcells with na‹ve and memory phenotypes, NK cells, eosinophils, basophils, dendritic cells and mast cells. The activity of RANTES however is not restricted merely to chemotaxis, moreover it is a powerful activator for T-cells, monocytes, neutrophils and NK cells, a feature potentially relevant in a range of inflammatory disorders.

Several CC chemokine receptors , including CCR-1, CCR-3, CCR-4 and CCR-5, have been shown to bind RANTES and subsequently to transduce a signal by increasing the intracellular calcium ion level.

Mouse RANTES cDNA encodes a 91 amino acid residue precursor protein that is cleaved to generate a 68 aa residue mature protein. At the amino acid sequence level, mouse RANTES ist 84% identical to human RANTES.

RANTES, amongst other chemokines, has been shown to play an important role in artherosclerosis, acute and chronic allergic inflammation, HIV suppression, food allergy and macrophage accumulation in the uterus during pregnancy. RANTES deficient mice showed impaired T-cell function.

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