Description: The mouse MCP-5 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of monocyte chemoattractant protein-5. The mouse MCP-5 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.
The chemokines are a large family of cytokines that control the recruitment of leukocytes in immune and inflammatory responses. Monocyte chemo attractant protein 5 (MCP-5) is a CC chemokine, based on its biological and structural features. Murine MCP-5 is mapped to the CC chemokine cluster on mouse chromosome 11 and is most closely related to human MCP-1 in structure. The chemokine is strongly chemotactic for monocytes and peritoncal macrophages, only weakly active on eosinophils and inactive on neutrophils. MCP-5 induces a calcium flux in peripheral blood mononuclear cells. Constitutive expression of this CC chemokine has been detected predominantly in lymph nodes, and its expression was markedly induced in macrophages.
MCP-5 is a potent monocyte active chemokine that is involved in allergic inflammation and the host response to pathogens.
Components
Aluminium pouch(es) with a Microwell Plate coated with Polyclonal Antibody to mouse MCP-5, Biotin-Conjugate (anti-mouse MCP-5 polyclonal antibody), Streptavidin-HRP and Sample Diluent, lyophilized
Aluminium pouch(es) with a mouse MCP-5 Standard curve (coloured)
Wash Buffer Concentrate 20x (phosphate-buffered saline with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Sample Diluent (Use when an external predilution of the samples is needed)
Stop Solution (1M Phosphoric acid)
Adhesive Plate Covers
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