MO MCP-3 INSTANT ELISA

• 产品编号：BMS6006INST      品牌：invitrogen       原厂货号：BMS6006INST
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: The mouse MCP-3 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of murine monocyte chemoattractant protein-3. The mouse MCP-3 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.

Chemokines represent a superfamily of small secreted proteins that function as intercellular messengers to control migration and activation of leukocytes involved in inflammatory reactions and immunity. Furthermore, chemokines are important mediators of many pathologies such as allergic responses, chronic inflammatory and autoimmune diseases, tumor growth and hematopoietic development.

MCP-3 is expressed at low levels when compared to MCP-1 from peripheral blood mononuclear cells in response to IFN-gamma as well as from a variety of tumor cell lines. MCP-3 is one of the most pluripotent chemokines since it activates all types of leukocytes, by binding to at least four different chemokine receptors. The natural protein is heterogeneous due to glycosylation and NH2-terminal processing. MCP-3 is a very potent chemoattractant for monocytes and T lymphocytes, respectively. Freshly isolated CD4+ and CD8+ lymphocytes as well as several T cell clones have been shown to migrate towards MCP-3. It has also been shown that dendritic cells respond to elevated levels of CC-chemokines like MCP-3 or RANTES. MCP-3 may also affect HIV-1 infection via inhibiting the binding of HIV envelope to CCR5, the co-receptor to HIV. Like for MCP-1, MCP-3 has also been implicated in Multiple Sclerosis, allergic reactions and viral infections. Furthermore the presence of MCP-3 has been described in several lung diseases, pathologies of the gastro-intestinal system and vernal keratoconjunctivitis.       

原厂资料：