Description: CD40L or CD154 is a membrane glycoprotein and differentiation antigen expressed on the surface of T-cells. The CD40 ligand stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines . CD40 ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also costimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma , TNF-alpha , and IL2 .
Biological Activity:
Determined by the stimulation of IL-12 induction by human peripheral blood mononuclear cells (PBMC). It also stimulates IL-8 induction by human PBMC using a concentration of 10-100 ng/mL.
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