Description: The human IP-10 Instant ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human IP-10. The human IP-10 Instant ELISA is for research use only. Not for diagnostic or therapeutic procedures.
IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. It plays a pivotal role in immune system development and deployment. The Interferon-gamma inducible protein -10kD (IP-10) displays pleiotropic functions including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis.
Through this inhibitory effect on neovascularization IP-10 exhibits anti-tumoral effects. It shares a common receptor, CXCR3, with the chemokine MIG, but has been shown to play a distinct role in host defense in infections. IP-10 is further involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer's disease.
Its involvement in the regulation of fibroproliferation following inflammatory lung injury has been described.
Components
Aluminium pouch(es) with a Microwell Plate coated with Monoclonal Antibody (murine) to human IP-10, Biotin-Conjugate (anti-IP-10 monoclonal antibody), Sample Diluent, and Streptavidin-HRP, lyophilized
Aluminium pouch(es) with a human IP-10 Standard curve (coloured)
Wash Buffer Concentrate 20x (phosphate-buffered saline with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Sample Diluent (Use when an external predilution of the samples is needed)
Stop Solution (1M Phosphoric acid)
Adhesive Plate Covers
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