Description: The human sVAP-1 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sVAP-1. The human sVAP-1 ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Lymphocyte binding to vascular endothelium is a prerequisite for the move- ment of immune cells from the blood into lymphoid tissues and into sites of inflammation. Under inflammatory conditions, cell surface expression of VAP-1 (vascular adhesion protein-1) which is an endothelial sialoglycoprotein, is induced. VAP-1 is a type II transmembrane protein of 84.6 kDa with a single transmembrane domain and N and O-glycosylation sites in the extracellular domain. In vivo, VAP-1 exists predominantly as a 180 kDa homodimer and functions both as an enzyme (monoamine oxidase) and an adhesion molecule for lymphocytes.
A circulating form of human Vascular Adhesion Protein-1 (sVAP-1) has been characterized. This sVAP-1 has been shown to be elevated in sera of patients with certain liver diseases and a correlation with the diagnosis of the patients was demonstrated.
Components
Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human sVAP-1
Biotin-Conjugate anti-human sVAP-1 monoclonal antibody
Streptavidin-HRP
Human sVAP-1 Standard lyophilized, 4 ng/ml upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films
京公网安备11010802025653 版权所有：北京逸优科技有限公司
