human Cu/ZnSOD Platinum ELISA

• 产品编号：BMS222TENCE      品牌：eBioscience       原厂货号：BMS222TENCE
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: The human Cu/ZnSOD ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human Cu/ZnSOD. The humanCu/ZnSOD ELISA is for in vitro diagnostic use. Not for use in therapeutic procedures.

Superoxide Dismutases (SODs) are a unique family of metalloproteins that catalyze the dismutation of superoxide anion radicals (O2-) to oxygen (O2) and hydrogen peroxide (H2O2)
O2- + O2- + 2H+ => H2O2 + O2
SOD is ubiquitous in oxygen metabolizing cells protecting these cells against direct and indirect oxygen-mediated free radical damage. Four types of SOD have been defined on the basis of distinctions in their metal cofactors and distribution: Manganese (MnSOD) principally located in the matrix of mitochondria of all aerobes, copper/zinc (Cu/ZnSOD) mainly present in the cytoplasm of eukaryotic cells, iron (FeSOD), predominantly in the cytosol, chloropasts or mitochondria of prokaryotes as well as extracellular (ECSOD), which is found in the extracellular fluids or membrane associated in mammals. The properties of Cu/Zn superoxide dismutase are quite different from those of the manganese or iron enzymes.

Induction of Cu/ZnSOD expression resulting in elevated levels of Cu/ZnSOD in human body fluids is of diagnostic value for measuring the activity of different diseases:

Nephropathies
Cu/ZnSOD determination provides a tool for early diagnosis of nephropathies.

Monitoring of therapeutic treatments
Cu/ZnSOD is a useful therapeutic tool in the treatment of chronic inflammation e.g. rheumatoid arthritis or of the ischemic myocardium in the phase of reperfusion. Due to the short half-life of SOD injected into the blood circulation, a rapid assay is necessary for monitoring SOD levels.

Trisomy 21 (Down's Syndrome)
In cases with Down's Syndrome an additional part of chromosome 21 is present in the genome of the patient as a structural chromosome aberration. The Cu/ZnSOD gene is localized on chromosome 21, closely associated with the gene complex responsible for the phenotype of Down's Syndrome. A gene-dosage effect for Cu/ZnSOD in Down's Syndrome providing a diagnostic marker for this syndrome has been described.
a) Patients with Down's Syndrome have significantly elevated serum and urine levels of Cu/ZnSOD.
b) Prenatal diagnosis of Down's Syndrome: Cu/ZnSOD levels are quantitated from erythrocytes of fetal umbilical vein blood and related to the number of cells, the content of haemoglobin and to the haematocrit. In case of Trisomy 21 the significantly elevated levels of Cu/ZnSOD are determined.

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