Description: The human sCD44var (v6) ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human sCD44var (v6). The human sCD44var (v6) ELISA is for research use only. Not for diagnostic or therapeutic procedures.
Alternative splicing of the mRNA gives rise to the different isoforms, containing inserts of varying sizes in the extracellular domain of the molecule (exons v2-v10). All CD44 isoforms are variably glycosylated. In contrast to standard CD44 (CD44std) which is almost ubiquitously expressed, the variety of CD44 isoforms (CD44var) have a much more restricted distribution, e.g., on activated lymphocytes and macrophages (exon v6).
The sCD44var(v6) ELISA detects all circulating CD44 isoforms comprising the sCD44var(v6) sequences.
Determination of sCD44var(v6) will provide more detailed insight into different pathological modifications during cancer and other diseases.
Components
Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human sCD44var (v6)
HRP-Conjugate anti-human sCD44var (v6) monoclonal antibody
Human sCD44var (v6) Standard lyophilized, 20 ng/ml upon reconstitution
Sample Diluent
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Adhesive Films
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