human MMP-13 Platinum ELISA

• 产品编号：BMS2022TEN      品牌：eBioscience       原厂货号：BMS2022TEN
• 产品分类：ELISA及其它免疫分析 > ELISA > ELISA检测试剂盒
• 应用分类：

描述：

Description: The human MMP-13 ELISA is an enzyme-linked immunosorbent assay for the quantitative detection of human MMP-13. The human MMP-13 ELISA is for research use only. Not for diagnostic or therapeutic procedures.

The matrix metalloproteinases (MMPs) represent a family of more than 15 Zn-dependent ndopeptidases with extracellular activity. They share a common conserved protease domain sequence in which three His residues form a complex with a catalytic Zn ion.

MMP-13, also known as Collagenase-3 has a broad substrate specificity and plays potential role in tumor metastasis and invasion. The three-dimensional structure reveals a core domain for the protein consisting of three alphahelices and five beta-sheet strands with an overall tertiary fold similar to the catalytic domain of the other matrix metalloproteinase family members. MMP-13 has originally been identified in breast carcinomas. MMP-13 and the expression of the enzyme is upregulated under conditions that promote endothelial cell growth and vascular differentiation. The over-expression of MMP-13 associated with nonhealing wounds is shown for chronic dermal ulcers. There is growing body of evidence that MMP-13 is a major player in the disease condition of rheumatoid arthritis and osteoarthritis.

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