ApoA-1 Pure 4/ApoA-1 50ug

产品编号：BD-612330 品牌：BD-Pharmingen 原厂货号：612330
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

In blood, cholesterol and triglycerides are transported in lipoprotein particles that consist of a single layer of phospholipid surrounding a lipid

core and surface-associated apolipoproteins (Apo). The Apo-proteins are involved in the specific binding of cellular receptors, the regulation

of lipolytic enzymes, and the process of lipid exchange. High density lipoprotein particles (HDLs) contain the apolipoproteins ApoA-I,

ApoA-II and Apo-M, whereas low density (LDL), intermediate density, and very low density (VLDL) lipoprotein particles contain ApoB-100

as the primary structural element. ApoA-I is synthesized in the liver and small intestines, where it acts as a cofactor for lecithin-cholesterol

acyltransferase during the formation of cholesterol ester. ApoA-II is synthesized in the liver where it activates hepatic lipase. In HepG2 cells,

treatment with gramoxone causes oxidative stress and reductions in ApoA-I mRNA levels. This down regulation of ApoA-I may contribute to

reduced plasma HDL levels in response to oxidants, such as cigarette smoke. Thus, ApoA-I is an important cofactor fo cholesterol synthesis

and is a major component of HDLs.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.