TOK-1 Pure 13/TOK-1 50ug

产品编号：BD-612326 品牌：BD-Pharmingen 原厂货号：612326
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Cell cycle progression is tightly regulated by the actions of cyclins and cyclin dependent kinases (Cdks). p21 forms a quaternary complex that

includes Cyclin D, Cdk4, and PCNA, and is induced during p53-dependent and -independent responses to cellular stress. p21 promotes cell

cycle arrest by preventing the phosphorylation and activation of Cdk. Although the Cdks are inhibited via direct interaction with the

N-terminal region of p21, various other proteins bind the C-terminal region. TOK-1 is a p21 interacting protein that exists as 50 kDa

(TOK-1α) and 45 kDa (TOK-1ß) isoforms. While both isoforms are primarily expressed in skeletal muscle, TOK-1ß is also expressed in a

variety of other tissues, including placenta and pancreas. Although both isoforms localize to the nucleus, TOK-1α, not TOK-1ß, is coexpressed

with p21 at the G1/S boundary and directly binds the C-terminal region of p21. TOK-1α has been shown to enhance the activity of p21,which

inhibits the H1 kinase activity of Cdk2. In addition, the TOK proteins were identified as BCCIPα and BCCIPß, which are nuclear proteins that

interact with BRCA2 and function in tumor suppression. Therefore, TOK-1 proteins may regulate cell cycle dynamics and cell transformation

through a variety of protein-protein interactions.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.