p23 Pure 16/p23 50ug

产品编号：BD-612320 品牌：BD-Pharmingen 原厂货号：612320
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through a process of ATP hydrolysis and the

interaction with exposed hydrophobic residues on substrate proteins. Members of the heat shock protein (Hsp) group of chaperones were so

named because their expression is rapidly induced upon heat shock or stress. Hsp90 and Hsp70 form complexes with chaperone accessory

factors, such as TCP-1, Hsp104, HiP, immunophilins (FKBP52 and FKBP51), HOP, Hsp40, Bag-1, and p23. A complex of Hsp90, Hsp70,

p48, Cyp-40, and p60 is known as the steroid aporeceptor complex that maintains a high affinity binding site in unbound intracellular

hormone receptors. p23 is a widely expressed chaperone-associated protein that interacts with the ligand-bound steroid holoreceptor complex,

and regulates holoreceptor-mediated transcriptional activity. In addition, p23/Hsp90 complexes may regulate telomerase complex assembly,

and remain associated with the active telomerase holoenzyme. Thus, p23 is a chaperone accessory factor involved in the assembly of protein

complexes, such as steroid hormone receptor and telomerase complexes.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.