GSK-3 Bta (pY216) Pure 13A 50ug

产品编号：BD-612312 品牌：BD-Pharmingen 原厂货号：612312
产品分类：抗体 > 一抗 > 磷酸化抗体
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

Glycogen Synthase Kinase-3β(GSK-3β) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and

down-regulating the activity of muscle glycogen synthase. GSK-3β

is identical to the Tau Protein Kinase I (TPK I) that plays a role in the

formation of the histopathological brain lesions of Alzheimer's disease (AD). Phosphorylation of the cytoskeletal protein, tau, by GSK-3β

converts these proteins into paired helical filaments (PHF) which are found in the neurofibrillary tangles and degenerative neurites of AD

patients. Regulation of GSK-3β

activity through both serine and tyrosine phosphoylation is a critical determinant of cell death or survival.

Factors that promote cell survival, such as growth factors, activate Akt which, in turn phosphorylates GSK-3β

at Ser-9, leading to inactivation

of its kinase activity. On the contrary, events that promote cell death, such as growth factor removal, cause increases in phosphorylation within

the catalytic domain at Tyr-216 and stimulate kinase activity. Thus GSK-3β

is a tightly regulated death promoting kinase that regulates the

activity of various proteins, including cytokeletal and enzymatic proteins.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.