p38 MAPK (pT180/pY182) Pure 30 150ug

产品编号：BD-612281 品牌：BD-Pharmingen 原厂货号：612281
产品分类：抗体 > 一抗 > 磷酸化抗体
应用分类：

包装：

150ug

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS).

Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-α. LPS-induced

signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). MAPK

signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation,

and death. The p38 MAP kinases include p38α, β, γ, and δ. These ser/thr kinases are activated by dual phosphorylation on Thr and Tyr within

the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the

MAPkinasekinases,

MKK3, MKK4, and MKK6. This leads to the activation of multiple transcription factors (NF-κB, ATF-2, Elk-1, and CHOP) that induce

expression of many different genes, including proinflammatory cytokine genes. Thus, p38 MAPKs are central kinases in muliple signal

transduction pathways.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.