NSF Pure 7/NSF 50ug

产品编号：BD-612272 品牌：BD-Pharmingen 原厂货号：612272
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Eukaryotic protein trafficking involves the packaging of target molecules into membraneous vesicles that bud from a donor compartment,

travel to a specific destination, fuse, and release their components into an acceptor compartment. Components of both the vesicle and the

plasma membrane interact to form a fusion complex, which mediates specific docking and fusion of vesicles. This complex contains NSF

(N-ethyl-maleimide-sensitive factor), SNAPs (soluble NSF attachment proteins), and receptor proteins (SNAREs). SNAP-25

(synaptosome-associated protein of 25kDa) and syntaxin are SNAREs that are associated with the target plasma membrane (t-SNAREs), while

synaptobrevin and synaptotagmin are vesicle-associated SNARE proteins (v-SNAREs). SNAREs form a 7S complex that has a high affinity

binding site for α-SNAP and NSF. Upon binding of α-SNAP and NSF, a 20S complex is formed that is rapidly disassembled due to NSF's

ATPase activity. This facilitates vesicle fusion to the target membrane followed by fusion and release of vesicle components.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

3.This antibody has been developed and certified for the bioimaging application. However, a routine bioimaging test is not performed on every lot. Researchers are encouraged to titrate the reagent for optimal performance.