ZRP-1 Pure 16/ZRP-1 150ug

Zyxin is a zinc-binding metalloprotein found in focal adhesion plaques. It contains a proline-rich N-terminal domain and a C-terminal domain

containing three LIM domains. LIM domains are characterized as zinc-binding motifs involved in gene expression and protein-protein

interactions. Zyxin related protein 1 (ZRP-1) was identified through its interaction with the second PDZ domain of PTP1E. ZRP-1 has also

been identified as Thyroid Receptor Interacting Protein-6 (TRIP6) during screening for binding partners of the thyroid hormone receptor.

ZRP-1 contains an N-terminal proline-rich region (PRR), and three double zinc finger LIM domains in the C-terminal region. ZRP-1 mRNA

has been reported to be widely expressed with strong expression in heart, placenta, lung, liver, kidney, and pancreas. ZRP-1 may interact with

focal adhesions similar to other LIM domain proteins in the zyxin-related subfamily. However, ZRP-1 also contains nuclear export signal, and

treatment of cells with leptomycin B leads to movement of ZRP-1 from the cytoplasm to the nucleus. Thus, ZRP-1 may be important for

relaying signals from focal adhesions to the nucleus.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.