Smac/DIABLO Pure 56/SMAC/DIABLO 50ug

产品编号：BD-612246 品牌：BD-Pharmingen 原厂货号：612246
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20° C.

到货周期：

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描述：

Apoptosis is a genetically programmed, selective process of cell death that occurs during normal cell differentiation and development of

multicellular organisms. Inhibitors of apoptosis proteins (IAPs), hILP/XIAP, c-IAP1, c-IAP2, and survivin, suppress apoptosis by preventing

procaspase activation and inhibiting mature caspase activity. Smac/DIABLO (second mitochondria-derived activator of caspases) eliminates

the inhibitory effect of many IAPs, and has been shown to interact with hILP, c-IAP1, c-IAP2, and survivin. The interaction with hILP occurs

through Smac/DIABLO binding to the second and third BIR domains of hILP. Smac/DIABLO protein contains an N-terminal mitochondria

targeting sequence (MTS) and a procaspase-3 activation domain. The N-terminal MTS is cleaved after import into the mitochondria, and the

activity of the mature Smac/DIABLO is dependent on homodimerization and release from the mitochondria. Overexpression of

Smac/DIABLO in HeLa cells increases the sensitivity to UV-mediated apoptosis. Thus, Smac/DIABLO acts as an apoptotic activator through

its binding to IAPs and activation of caspases.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.