During neural development, many axons must travel long distances before reaching their dendritic targets and establishing synapses. After
injury, these axonal connections can only regenerate in the peripheral nervous system, but not in the central nervous system (CNS). This
difference in axon regeneration is thought to involve various inhibitory molecules found in the myelin of axons in the CNS. Nogo was
identified in assays that examined fractions from myelin extracts for the antigen of monoclonal antibody IN-1, an antibody that allows modest
axon regeneration after spinal cord injury. Nogo is expressed as three different proteins, Nogo-A, -B, and -C, which are members of the
Reticulon family of ER anchoring proteins. Nogo-A is the full length protein, while Nogo-B contains 172 amino acids of the N-terminus and
188 amino acids of the C-terminus of Nogo-A, and Nogo-C contains only the 188 amino acid C-terminus of Nogo-A. These splice variants are
all found in optic nerve, spinal cord, and cerebral cortex, but differ in expression in other neuronal and non-neuronal tissues. Thus, Nogo-A is
a myelin-associated protein that may have roles in the ER, as well as during axon regeneration.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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