Cytokine function is critical for both innate and adaptive immune responses. Interferon (IFN) signal transduction pathways involve a variety of transcription factors that bind specific DNA motifs called IFN-stimulated response elements (ISRE) and IFN γ-activated sequences (GAS). The IFN regulatory factor (IRF) family is a group of transcription factors that bind to these DNA motifs and regulate the activity of IFN-responsive genes. The IRF family is comprised of seven different proteins (IRF1 to IRF7) that have been identified due to their interaction with ISRE and GAS sequences. IRF1 functions in the activation of IFN-responsive genes during induction of histocompatibility antigens, and inhibition of cell proliferation. In addition, IRF1 may function as a tumor suppressor, since deletions in the IRF1 locus is associated with myelodysplasia and leukemias. IRF2 is thought to be a transcriptional repressor, while others like IRF3 and IRF4 may function as activators or repressors depending on the specific promoter. In lymphocytes, IRF4 is required for normal development and function. Thus, IRFs regulate the activity of IFN-responsive genes required for normal immune function.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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