PITPs (phosphatidylinositol transfer protein) are abundant cytosolic or transmembrane proteins that are required for phospholipase C (PLC) signaling and vesicular trafficking. All of the mammalian PITPs are homologous to Drosophila retinal degeneration B (rdgB) proteins, which are PITPs that are involved in retinal and olfactory neurosensory signaling, and mutations in these proteins lead to retinal degeneration. There are at least 5 mammalian PITPs, three cytosoloic PITPs, PITPα, PITPβ, and MrdgBβ, and two transmembrane PITPs: PITPnm (Nir2/MrdgBα) and Nir3. PITPα and β participate in PLC signaling, mediated by the ability of PITP to deliver PI to the signaling complex containing PI4-Kinase, PIP-5-Kinase, and the activated receptor. PITPnm contains an N-terminal PITP domain adjacent to a Ca2+-binding domain (CBD), and a C-terminal PYK2 binding domain. PITPnm mRNA is widely expressed with the highest expression in brain, and PITPnm protein is found in the ER and Golgi. Thus, PITPnm may be important for phosphoinositide synthesis in the Golgi, and may interact with PYK2 during activation of PI-4 signaling pathways.
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1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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