LR11 Pure 48/LR11 150ug

The low-density lipoprotein receptor (LDLR) functions in lipoprotein transport pathways, and is involved in familial hypercholesterolemia.

Homologues of the LDLR may have diverse functions and their ligands may include biological inactive plasma carrier complexes, plasma

lipoproteins, yolk precursors, toxins, and extracellular lipoproteins. LR11 (also known as sorLA-1 and gp250) is a lipoprotein receptor

homologue that contains 11 LDL receptor ligand binding repeats (LDLRs), 5 LDL receptor "YWTD"repeats, a large fibronectin-type III (FIII)

hexarepeat domain similar to neural adhesion proteins, and a domain with similarity to the yeast receptor for vacuolar protein sorting

(Vsp10p). LR11mRNA is expressed at high levels in brain, but is also found in liver, pancreas, adrenal gland, and testis. LR11 can bind the

ER and Golgi localized receptor associated protein (RAP), which binds to many members of the LDLR family and prevents aggregation of

ligands to the LDLRs. In addition, LR11 binds apolipoprotein E-containing lipoproteins. Thus, LR11 is a lipoprotein binding receptor that

may have additional functions related to protein sorting and neuronal development.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.