BAF60a Pure 23/BAF60a 50ug

产品编号：BD-611728 品牌：BD-Pharmingen 原厂货号：611728
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20° C.

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描述：

SWI/SNF complexes facilitate gene activation and transcription factor binding byaltering repressive chromatin structures. In mammals,

SWI/SNF complexes are present inmutliple forms that include 9-12 proteins called BRG1-associated factors (BAFs), whichrange in molecular

weight from 47 to 250 kDa. BAF60 is the homologue of the yeastSWP70 subunit of the yeast SWI/SNF complex that regulates

glucocorticoidtranscription. Three isoforms of BAF60 are BAF60a, BAF60b, and BAF60c. BAF60a isubiquitously expressed and is present in

the 200-kDa BRG1 complex. BAF60b andBAF60c are expressed preferentially in muscle and pancreas and may be subunits of adistinct

complex that shares some subunits with BRG1 complex. In hematopoietic cells,a SWI/SNF related-complex (PYR) contains BAF57, INI1,

BAF60a, and BAF170. This complex binds a 250 bp pyrimidine-rich element between the fetal and adult ß-globingenes and may facilitate

human fetal-to-adult globin gene switching. Thus, BAF60proteins are components of multiple SWI/SNF complexes that regulate the

transcriptionof various genes.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.