The development of cancer is a multi-step process involving DNA alterations, oncogene activation, and/or the inactivation/deletion of an
anti-onocogene or tumor suppressor. Tumor suppressors are involved in many facets of cell biology,such as cell cycle regulation and
development. FEZ1 (F37/Esophageal cancer related gene-coding leucine zipper motif) is a putative DNA-binding protein with homology to
cAMP-responsive activating-transcription factor 5 (Atf-5). The structure of FEZ1 includes DNA-binding and leucine zipper domains at amino
acids 301-369 , as well as a putative cAMP-dependent phosphorylation site at Ser-29. FEZ1 is ubiquitously expressed in normal tissues with
the most abundant expression in testes and brain, but is absent in 31 different cancer cell lines and 16 primary tumors. In addition, the FEZ1
gene has missense mutations in two primary esophageal cancers and a nonsense mutation in a prostate cancer cell line. Several
FEZ1-expressing tumors have internally truncated FEZ1 mRNA transcripts. Thus, FEZ1 inactivation in cancers may involve both allelic loss
and point mutations and implicates FEZ1 in cAMP-dependent tumor suppression.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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