KNP-1 Pure 35/KNP-1/HES1 150ug

产品编号：BD-611597 品牌：BD-Pharmingen 原厂货号：611597
产品分类：抗体 > 一抗 > 蛋白特异性一抗
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包装：

运保温度:

Store undiluted at -20°C.

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描述：

Human chromosome 21 has been extensively studied because trisomy 21 causes Down syndrome. In addition to this syndrome, chromosome

21 is the loci for five other hereditary disorders, myoclonus epilepsy, autoimmune polyglandular disease type I, nonsyndromic hereditary

deafness, Knobloch syndrome, and bipolar affective disorder. Exon trapping studies of human chromosome 21q22.3 identified transcriptional

units with homology to the zebrafish ES1 and the E. coli sigma cross-reacting protein 27A (SCRP27A). The human ES1 homolog (HES1) was

also identified as KNP-1α/KNP-1β, as well as GT335 in similar screens for genes involved in disorders that map to chromosome 21q22.3.

KNP-1/HES1 mRNA is ubiquitously expressed with the highest expression in muscle and heart. KNP-1/HES1 protein contains putative

mitochondrial targeting signals and localizes to mitochondria in mouse NIH 3T3 cells. Interestingly, mitochondrial deletions have been

implicated in syndromes related to deafness. Thus, KNP-1/HES1 may be a mitochondrial protein important for normal development, and may

be a candidate gene for disorders related to deletions at chromosome 21q22.3.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.