MUPP1 Pure 43/MUPP1 150ug

The postsynaptic density protein PSD-95 interacts with the cytoplasmic tail of ion channel subunits via a protein-protein motif called the PDZ

domain. PSD-95 belongs to a family of PDZ domain-containing proteins that includes SAP97/Dlg, PSD-93/chapsyn-110, and SAP102. These

proteins are characterized by three PDZ domains in the N-terminal half and an SH3 and guanylate kinase-like domain in the C-terminal region.

They may be involved in the localization and clustering of ion channels and receptors at synaptic sites. Other PDZ domain-containing proteins

such as glutamate receptor interacting protein (GRIP), Homer, and multi-PDZ-domain protein (MUPP1) do not contain guanylate kinase-like

domains, but have also been implicated in receptor localization. MUPP1 contains thirteen PDZ domains and is expressed in human heart,

brain, placenta, liver, skeletal muscle, kidney, and pancreas. In addition, smaller variants of MUPP1 are expressed in heart, liver, kidney, and

brain. The C-terminal region of the 5-HT2c receptor interacts with MUPP1, suggesting that MUPP1 may have important protein-protein

interactions during G-protein coupled receptor signaling.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.