The catenins (α, β, γ, δ, p120[ctn]) are cytoplasmic proteins that are related to the Drosophila Armadillo protein. Catenins may have dual roles
since they are components of cell-cell adherens junctions and can translocate to the nucleus after stimulation of the Wingless (Wnt-1
homolog) signaling pathway. α-Catenin has two subtypes: αE-Catenin, which is expressed ubiquitously, and αN-Catenin, which is expressed
in the nervous system. β-Catenin binds to the cytoplasmic tail of E-Cadherin at adherens junctions and has been implicated in Wnt-1 signaling.
γ-Catenin is associated with desmoglein in desmosomes and is closely related to β-Catenin. p120[ctn] is related to both β- and γ-catenin and is
a substrate of tyrosine kinases localized at adherens junctions. δ-catenin was identified by its ability to bind the Alzheimer's disease-related
protein, presenilin-1. It is most closely related to p120[ctn] and the desmosomal protein, p0071. It contains 10 Armadillo (Arm) repeats, as
compared to the 13 Arm repeats found in β-Catenin. δ-Catenin is expressed at high levels in the developing nervous system, where it may be
involved in neuronal progenitor cell migration and dendrite development.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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