Ceruloplasmin Pure 8/Ceruloplasmin 150ug

cGMP is involved in nitric oxide signaling, as well as cell signaling associated with natriuretic peptides and guanylins. Intracellular targets for

cGMP include cGMP-dependent protein kinase, cyclic nucleotide-gate ion channels, and cGMP-Binding PhosphoDiesterases (cGB-PDE).

Tissue levels of cGMP are determined by guanylyl cyclases that catalyze the formation of cGMP and cyclic nucleotide PDEs that catalyze the

breakdown of cGMP. In the PDE superfamily PDE2, PDE5, PDE6, and PDE10 have dimeric structures that contain highly cGMP-specific

allosteric cGMP binding sites in addition to a phosphodiesterase catalytic site. PDE5 is highly expressed in aorta and lung, but is also

expressed in intestine, kidney, adrenal gland, cerebellum, and cerebrum. In the cerebellum, PDE5 is expressed in the Purkinje cell layer during

neonatal development. PDE5 is also abundant in vascular smooth muscle cells where it is involved in regulating cGMP levels and vascular

smooth muscle tonicity. Thus, PDE5 is important for regulating cGMP levels in both neuronal and non-neuronal tissues that utilize cGMP

signaling pathways for the regulation of cell function.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.