AP50 Pure 31/AP50 50ug

产品编号：BD-611350 品牌：BD-Pharmingen 原厂货号：611350
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Sorting of integral membrane proteins is mediated vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based

and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated

with the vesicle coats. These coatomers contain two large adaptin proteins (

γ,α,δ,ε, andβ1,β2,β3,β4 respectively) that are noncovalently

linked to one medium chain (μ1, μ2, μ3, μ4 respectively) and one small chain (σ1,

σ2,σ3,σ4 respectively). The AP-1 and AP-3 complexes

are involved in protein sorting from the TGN and endosomes, while AP-2, μ2 (AP50) interacts with integral membrane proteins via binding to

tyrosine-based signals with the canonical motif YXXΦ. In addition, AP50/μ2 is required for both the assembly and the proton transport

activity of vacuolar (H+)-ATPases in clathrin coated vesicles. Thus, AP50/μ2 may be involved in targeting integral membrane proteins that are

sorted based on tyrosine-based signals and involved in assembly of functional ion channels associated with clathrin coated vesicles.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.