Plectin Pure 31/Plectin 50ug

产品编号：BD-611348 品牌：BD-Pharmingen 原厂货号：611348
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Plectin is an intermediate filament-binding protein that acts as a cross-linking elementin the cytoskeleton. Sequence analysis reveals that

plectin is dumbbell shaped and contains a long central α-helical coiled-coil rod flanked by globular domains. Plectinhas six C-terminal repeats

that exhibit a tandemly repeated amino acid sequence motif that is characteristic of intermediate filament-associated proteins, such as BPAG1

and desmoplakin. Plectin associates with the sarcolemma, nuclear membrane, and intermyofibrillar network in muscle and with

hemidesmosmes in skin. These localizations may be a result of plectin binding to a variety of cytoskeletal proteins including laminin B,

microtubule-associated proteins, and α-spectrin. In addition, plectin interacts with G-actin in a PIP2-dependent manner and with actin stress

fibers viaits N-terminal actin-binding domain. Patients with epidermolysis bullosa simplex, adisease that results in structural and functional

abnormalities in muscle and skin, have no plectin expression in muscle tissues and deficient plectin levels in skin. Thus, plectin cytoskeletal

association may be critical for the structural integrity of muscle and skin.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.