PI3-Kinase C2 Bta Pure 22/PI3-K 50ug

产品编号：BD-611342 品牌：BD-Pharmingen 原厂货号：611342
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

Phosphatidylinositol (PtdIns) (3) kinase phosphorylates the D-3 position of the inositolring of PtdIns, producing PtdIns(3)P, PtdIns(3,4)P2,

and PtdIns(3,4,5)P3. PI3-kinase is a heterodimer of an 85 kDa regulatory subunit (p85) and a 110 kDa catalytic subunit (p110). However, it is

only one member of a larger family of proteins with similarity to the p110 subunit. These different PI3-kinase isoforms have been divided into

three classes. Class I consists of p110

α and p110ß which bind the p85 subunit and associate with receptor tyrosine kinases. Class II includes 68D and cpk from Drosophila , p170 and cpk-m from mouse, and C2α, C2ß (HsC2), and C2γ from human. These proteins phosphorylate

PtdIns and PtdIns(4)P, but not PtdIns(4,5)P2, and each contain a C-terminal C2 domain that may negatively regulate the catalytic domain.

Class III members only phosphorylate PtdIns to PtdIns(3)P and include the

S. cerevisiae

Vps34p and its human homologs. In humans, the

class II PI3-kinases C2α and C2ß have similar catalytic, PI kinase, and C2 domains. However they differ in their N-terminal regions. In addition, C2ß has no cation specificity, while C2α

prefers Mg2+-ATP for optimal phosphorylation.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.