SNX2 Pure 13/SNX2 50ug

Biological processes such as transmembrane signaling and receptor mediated endocytosis revolve around the function of cell surface receptors.

A network of molecular machinery directs the intracellular trafficking of receptors during their biosynthesis and mediates signaling

downstream of receptors. The sorting nexins (SNX1, SNX1A, SNX2, SNX3, and SNX4) are a family of intracellular proteins that are thought

to direct the sorting of receptor proteins. The SNX proteins contain a conserved 100 amino acid region termed the phox homology (PX)

domain and are part of a family of hydrophilic proteins which includes S. cerevisiae proteins that function in protein sorting. SNX1, SNX2,

and SNX4 associate predominantly with membranes and bind transmembrane receptors such as those for EGF, PDGF, and insulin. SNX1

directs the EGF receptor to the lysosomes for degradation. SNX2 forms homomeric complexes and heteromeric complexes with SNX1,

SNX1A, and SNX4. These complexes are thought to be necessary for efficient protein sorting. Thus, SNX2 and other sorting nexins are

thought to play important roles in the specificity of protein trafficking to and from the plasma membrane.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.