pICln (I = current, Cl = chloride, n = nucleotide-sensitive) was initially described as an integral component of a nucleotide-sensitive chloride
channel. However, it lacks homology to known channel proteins and exhibits cytoplasmic and nuclear localization. Thus, pICln is thought to
be a cytosolic regulator of a swelling-induced chloride channel, rather than a component of a channel itself. In support of this hypothesis,
pICln interacts with several cytosolic proteins. It binds to several Sm proteins, which are common spliceosomal core proteins whose assembly
is necessary for the biogenesis of small nuclear ribonucleoproteins (snRNPs). Sm protein association with pICln inhibits their assembly. pICln
also interacts with the 72 kDa human homolog of Skb1, a yeast protein that binds a homolog of p21[Cdc42/Rac]-activated protein kinases. In
addition, pICln interacts with, and is phosphorylated by, a constitutively active cytosolic protein kinase. Therefore, pICln is thought to be a
component of signaling pathways that function in transcriptional or translational regulation, cytoskeletal reorganization, or a number of other
biological processes.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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