Neuropilin-2 Pure 54/Neuropilin-2 50ug

The precise navigation of axons to their targets in the developing nervous system is essential for establishment of neuronal connectivity.

This is achieved through the recognition of attractant and repellent signals delivered to neurons by the netrins and semaphorins, which

interact with receptors on axons and growth cones. The semaphorins are a large family of secreted and transmembrane glycoproteins that

function as chemorepellents of developing neurons. Neuropilin-1 (NP-1) and neuropilin-2 (NP-2) (44% amino acid identity) are receptors

for various members of the secreted semaphorin family. While NP-1 binds to class III semaphorins (Sema III, Sema E, and Sema IV), NP-2

is a high affinity receptor for Sema E and Sema IV, but not Sema III. Although they interact with distinct but overlapping subsets of

semaphorins, NP-1 and NP-2 exhibit unique expression patterns during nervous system development. Moreover, NP-1 and NP-2 can form

homooligomers which can, in turn, form heterooligomers. Thus, their interactions and differential patterns of expression implicate NP-1 and

NP-2 in the coordination of axon guidance during neurodevelopment.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.