Microtubules, integral components of the cytoskeleton, are essential for establishment of cell polarity, membrane structure organization, and organelle translocation. Cell polarity is accomplished through the linkage of microtubules to other cytoskeletal proteins by microtubule associated proteins (MAPs). Likewise, the process of organelle translocation requires accessory proteins that link the organelles to microtubules. These proteins are known as CLIPs (cytoplasmic linker proteins) and belong to a novel family of microtubule binding proteins that are characterized by the presence of N-terminal microtubule binding (MTB) domains. CLIP-115 was discovered due to its high degree of homology to CLIP-170 (restin), which links endosomes to microtubules. Like CLIP-170, CLIP-115 contains two MTB domains and a long coiled-coil region. CLIP-115 has been reported to be found primarily in the brain where it associates with microtubules and the dendritic lamellar body (DLB). DLBs have been reported to be organelles that are present exclusively in the bulbous dendritic appendages of neurons. It is thought that CLIP-115 is a protein constituent of DLBs and is responsible for determining their structure and cytoplasmic location.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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