Neurotransmitter release is mediated by the synaptic vesicle cycle at the presynaptic nerve terminal. This exocytic process involves vesicle docking at the plasma membrane, which is followed by priming and fusion. Following exocytosis, the empty vesicles are recycled for continued neurotransmitter release. Vesicle fusion is mediated by a protein complex consisting of both synaptic vesicle and synaptic plasma membrane components, such as synaptotagmin, synaptobrevin, and synaptogyrin. It is thought that synaptic vesicle-mediated exocytosis is very similar to other exocytic pathways. In line with this idea, cellugyrin is a synaptogyrin-like protein that is widely expressed in non-neuronal tissues. Cellugyrin and synaptogyrin share 47% amino acid sequence identity. Additionally, both cellugyrin and synaptogyrin are phosphorylated in their cytoplasmic tails by pp60c-src. This suggests a role for phosphorylation in the regulation of membrane trafficking. Thus, cellugyrin is a ubiquitously expressed exocytic protein of which synaptogyrin is a specialized neuronal version. However, the exact function of either protein in exocytosis remains to be determined.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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