Cathepsin L is a major lysosomal cysteine protease that plays an important role in intracellular protein catabolism and turnover. The 43kDa precursor form is processed to a mature form that localizes to the cell surface and is also secreted. The conversion from the proenzyme to the mature form of Cathepsin L is influenced by cell-cell contact and extracellular matrix components such as heparan sulfate and glycosaminoglycans. Cathepsin L processes several extracellular proteins (laminins, fibronectin, collagen, elastin) as well as serum proteins, and cytoplasmic and nuclear proteins. Its synthesis and secretion can be induced by tumor promoters, growth factors, and second messengers. It is believed to be an important player during metastasis because of the large quantities found in human tumors as well as in transformed cultured cells. Therefore, Cathepsin L is an active cysteine protease that plays a critical role in growth regulation, tumor invasion and metastasis, and bone resorption.
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注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
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