Many aspects of cellular physiology are influenced by the serine/threonine protein phosphatase1 (PP1). It is a highly conserved eukaryotic protein that reverses the action of protein kinases. PP1 is key to such processes as cell division, neuronal metabolism, and protein synthesis. It consists of a catalytic subunit, with a broad substrate specificity, whose action is directed by its association with a family of regulatory proteins including inhibitor-1, inhibitor-2, and NIPP-1. In response to extracellular stimuli, these proteins interact with PP1 and inhibit its catalytic activity. Other regulatory proteins are referred to as targeting subunits because they direct PP1 to specific subcellular locations and modulate its activity. In the cell nucleus, PP1 has been implicated in a variety of processes. Nuclear PP1 exists in high MW complexes with other proteins including NIPP-1. PNUTS (phosphatase 1 nuclear targeting subunit) is a ubiquitously expressed nuclear protein that forms a stable complex with PP1 and is thought to modulate its catalytic activity. Thus, PNUTS is a specific regulatory protein that directs the nuclear function of PP1.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
