Cell division is a highly regulated process which ensures that properly replicated DNA is received by both daughter cells. During M phase, the pairs of sister chromatids separate into each daughter cell. To ensure correct cell division, each step of this process is highly regulated by proteins such as kinases and phosphatases that serve as checkpoints. HEC (highly expressed in cancer) was discovered during a search for mitotic proteins that might provide insight to the progression of malignant cells. HEC was identified via its interaction with Rb (retinoblastoma protein) in the yeast two hybrid system. Its expression is elevated during M phase, and it localizes to the centromeres during this time of rapid division. During G1 HEC is dispersed in the nucleus. In addition, HEC is abundant in rapidly dividing cancer cells, but is absent from terminally differentiated cells. Also, microinjection of HEC antibodies resulted in abnormal chromosome distribution. Therefore, HEC is thought to play a role in chromosome segregation during the M phase of the cell cycle.
原厂资料：
注意事项：
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
京公网安备11010802025653 版权所有：北京逸优科技有限公司
