PITP Pure 50/PITP 50ug

产品编号：BD-611024 品牌：BD-Pharmingen 原厂货号：611024
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

PITP (Phosphatidylinositol Transfer Protein) is an abundant cytosolic protein that is required for phospholipase C (PLC) signaling and

vesicular trafficking. Mammalian cells contain the two PITP isoforms α and β, which bind to lipids with different affinities. PITPα contains a

single lipid-binding site and reversibly binds phosphatidylinositol (PtdIns) and phosphatidylcholine (PC), then transfers them between

membrane compartments. PITPα exhibits a much higher affinity for PtdIns than for PC. PITPα and β participate in PLC signaling, mediated

by the ability of PITP to deliver PtdIns to the signaling complex containing PI4-Kinase, PIP5-Kinase, and the activated receptor. A retroposon

insertion in the murine gene encoding PITPα interferes with RNA accumulation and is thought to be the primary cause of the mouse

vibrator

mutation, a neurodegenerative disorder. Thus, PITP mediates the intracellular transfer of phospholipids, which is central to processes such as

PLC signaling, exocytosis, and secretory vesicle formation. More importantly, PITPα and PtdIns signaling pathways, in general, may be

critical targets in mammalian neurodegenerative disorders. Due to high homology levels between the PITPα and β isoforms, this antibody may

cross react with PITPβ.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.