CD49b Pure 2/CD49b 50ug

产品编号：BD-611016 品牌：BD-Pharmingen 原厂货号：611016
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

到货周期：

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描述：

Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large α chain that is

non-covalently associated with a smaller β chain which is used to define integrin subfamilies. These molecules exhibit a wide range of

expression throughout development and adulthood. VLA-2 (very late antigen), a member of the integrin superfamily, was identified on

activated T cells, but has since been reported to be on various cell types. VLA-2 is reported to be a heterodimer of integrin α2 (CD49b) and

integrin β1 (CD29) subunits. The α2 chain contains a large extracellular domain, a transmembrane domain, and a short cytoplasmic tail.

VLA-2 functions as a collagen receptor on platelets and fibroblasts, as well as a collagen and laminin receptor on endothelial and epithelial

cells. On activated T cells, VLA-2, like LFA-1, exhibits increased number and affinity of ligand binding. Interactions of these molecules with

their extracellular matrix ligands is important for directing effector T cells to their target tissues and to provide co-stimulatory signals. Thus,

VLA-2 not only plays an important role in cellular adhesion, but may function in intracellular signal transmission.

This antibody is routinely tested by western blot analysis. Other applications were tested at BD Biosciences Pharmingen during antibody

development only or reported in the literature.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.