PI3-Kinase p110 Dta Pure 29 50ug

产品编号：BD-611014 品牌：BD-Pharmingen 原厂货号：611014
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20°C.

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描述：

Phosphoinositide 3 Kinase (PI3 Kinase) phosphorylates the D-3 position of the inositol ring of phosphatidylinositol, producing PtdIns(3)P,

PtdIns(3,4)P2, and PtdIns (3,4,5)P3. PI3-kinase is a heterodimer of an 85 kDa regulatory subunit (p85) containing two SH2 domains and an

SH3 domain, and a 110 kDa catalytic subunit (p110). Four isoforms of p110 have been identified (α , β , γ, and δ). The p110α, β isoforms are

distributed ubiquitously. The p110δ isoform is found exclusively in lymphocytes and lymphoid tissues. Lymphocytes also contains p110α and

both isoforms interact with p85 and are recruited to activated signaling complexes. However, several biochemical and structural differences

distinguish p110δ. Unlike p110α, p110δ autophosphorylates and does not phosphorylate p85. In addition, p110δ contains a Pro-rich region,

which endows it with the potential for interaction with SH3 domain-containing proteins, and a bZIP-like domain, which is a common

transcription factor domain that has also been identified in certain protein kinases. With the established role of PI3-Ks in cytoskeletal

rearrangements, it is thought that p110δ contributes specifically to the regulation of lymphocytes extravasation into tissues. There is a high

degree of homology in the immunogen region with the P110β form (77%), and it is likely that our antibody will detect both the beta and delta

forms.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.