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CD51 Pure 21/CD51 50ug

  • 产品编号:BD-611012      品牌:BD-Pharmingen       原厂货号:611012
  • 产品分类:抗体 > 一抗 > 蛋白特异性一抗
  • 应用分类:
 
包装: 50ug
运保温度: Store undiluted at -20°C.
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标准价: ¥客户可见
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描述:

Integrins are a family of proteins that mediate intercellular adhesion or adherence to extracellular matrix proteins. Their roles are essential for
embryonic development, tumor metastasis, organ function, and proper immune cell function. Family members are heterodimers that contain a
larger α subunit that is unique to each individual receptor and a smaller β subunit that can be shared by several receptors. Based on β subunit
content, integrins are divided into the subfamilies β1, β2, and β3. The β3 subfamily contains the vitronectin receptor (αVβ3) and the platelet
protein gpIIb/IIIa. The α chain of the vitronectin receptor (VNRα, CD51, integrin αV) has been reported to consist of a disulfide-linked large
extracellular (125 kDa) subunit and a smaller (25 kDa) membrane-anchored subunit. The large subunit contains multiple sequences with
homology to calcium-binding sites in other proteins and an RGD-dependent ligand-binding site, while the small subunit contains a
transmembrane domain and a short cytoplasmic domain. VNRα has been reported to be noncovalently associated with the VNR β3-chain
(CD61, gpIIIa). The VNR mediates cell adhesion to RGD-containing ligands such as vitronectin, von Willebrand factor, fibrinogen, and
thrombospondin.


注意事项:

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.


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