Dynactin p50 Pure 25/Dynactin p50 150ug

产品编号：BD-611003 品牌：BD-Pharmingen 原厂货号：611003
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

150ug

运保温度:

1.Since applications vary, each investigator shoul

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描述：

Dyneins are ubiquitous, multimeric proteins that are responsible for minus end-directed microtubule-based organelle transport. They are

divided into two classes, cytosolic and axonemal. The activity of cytosolic dynein is regulated by the multiprotein dynactin complex with

which it co-purifies. Dynactin is composed of at least nine polypeptides with p50 being the second most abundant subunit. The complex

consists of an F-actin-like core filament of actin-related protein Arp1, a heterodimer that acts as a cap at one end, and a 62kDa subunit at the

other end. p150[glued] is the largest subunit of the complex. The precise function of dynactin remains to be determined, but it may be

recruited to prometaphase kinetochores to assist in alignment and spindle organization during mitosis. Additionally, dynactin localizes at the

tail of cytosolic dynein and activates dynein-mediated vesicle movement. Therefore, dynactin may function to anchor or target dynein to the

kinetochore during mitosis.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3.Store undiluted at -20°C.