GS15 Pure 19/GS15 150ug

Eukaryotic protein trafficking involves the packaging of target molecules into membranous vesicles that bud from a donor compartment, travel

to a specific destination, fuse, and release their components into an acceptor compartment. Components of both the vesicle and the synaptic

plasma membrane interact to form a fusion complex which mediates specific docking and fusion of vesicles. This complex contains NSF

(N-ethyl-maleimide-sensitive factor), SNAPs (soluble NSF attachment proteins), and receptor proteins (SNAREs) that include synaptobrevin,

synaptotagmin, syntaxin, and SNAP-25 (synaptosome-associated protein of 25 kDa). SNAP-25 and syntaxin are associated with the target

plasma membrane (t-SNAREs), while synaptobrevin and synaptotagmin are vesicle-associated proteins (v-SNAREs). In Drosophila, protein

transport from the ER to Golgi involves Bet1p, a v-SNARE. With 28% amino acid identity to Bet1p, GS15 (Golgi SNARE of 15 kDa) is

widely expressed in rat tissues. It is an integral membrane protein of the Golgi apparatus and functions as a SNARE. Thus, GS15 is thought to

be a novel SNARE that participates in ER-Golgi protein transport through an undefined process.

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.