MEK5 Pure 21/MEK5 50ug

产品编号：BD-610956 品牌：BD-Pharmingen 原厂货号：610956
产品分类：抗体 > 一抗 > 蛋白特异性一抗
应用分类：

包装：

50ug

运保温度:

Store undiluted at -20° C.

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描述：

The mitogen-activated protein (MAP) kinase cascade participates in the Ras signal transduction pathway. The MAP kinase cascade consists of

MEK kinase (Raf-1 or B-Raf), MAP/ERK kinase (MEK1 or MEK2), and extracellular-regulated protein kinase (ERK1 or ERK2). Raf

becomes activated following its interaction with Ras-GTP (activated Ras). Via phosphorylation reactions, Raf activates MEK which, in turn,

activates ERK. MEK5, also known as MAP Kinase 5, is a 50 kDa protein that is 40% identical to MEK1 and MEK2. Alternative splicing

results in two MEK5 isoforms: α (50 kDa) and β (40 kDa). MEK5β has been reported to be ubiquitously expressed while MEK5α is expressed

primarily in the liver and brain. The N-terminal amino acid sequence of MEK5α resembles sequences found in actin cytoskeletal proteins,

indicating that MEK5α may associate with the cytoskeleton. However, the role of MEK5 in the MAP kinase pathway and its substrate remain

to be identified.

注意事项：

1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.

2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.