CLA-1 (CD36 and LIMPII Analogous-1) is member of a novel gene family that includes CD36, LIMPII, and SR-BI. CD36 is a cell surface
glycoprotein that binds to collagen type I and thrombospondin. LIMPII (lysosomal integral membrane protein II), as its name suggests, is
expressed on the membrane of lysosomes. SR-BI (scavenger receptor type B class I) is involved in the selective uptake of cholesterol esters.
These proteins include two membrane-anchoring regions, two short cytoplasmic tails, and a large extracellular/luminal domain. CLA-1 mRNA
is detected in a wide range of tissues including adrenal glands, liver, and testis. Its expression and similarity with other family members
suggest it may play a role in HDL metabolism. However, identification of the CLA-1 receptor on monocytes indicates additional CLA-1
functions in leukocytes.
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注意事项:
1.Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2.Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.